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Association between Brachycephaly, Chiari Malformation, and Basilar Invagination
Ricardo Vieira Botelho1, Pedro Bittencourt Botelho2, Bruna Hernandez3
1Department of Neurosurgery, Inst Assistencia Med Ao Serv Publ Estadual Sao Pa, São Paulo, Brazil.
Basilar invagination (BI) is linked to brachycephaly, a condition of a shorter, wider head. This study found BI patients had a significantly higher cephalic index (CI) than controls, confirming this association.
Area of Science:
- Neurosurgery
- Radiology
- Genetics
Background:
- Chiari malformation (CM) and basilar invagination (BI) may stem from posterior fossa volume/content disproportion.
- Brachycephaly shows an increased association with BI.
- Craniosynostosis, particularly coronal, can reduce posterior fossa volume.
Purpose of the Study:
- To evaluate the association between Chiari malformation (CM) and basilar invagination (BI).
- To investigate the relationship between cephalic index (CI) and BI in patients with craniocervical malformations.
Main Methods:
- Cephalic index (CI) was measured using MRI.
- CI of patients with craniocervical malformation was compared to that of normal subjects.
Main Results:
- Patients with basilar invagination (BI) exhibited a significantly higher average cephalic index (CI) compared to normal subjects.
- BI patients had the highest CI within the entire craniocervical junction malformation (CVJM) cohort.
Conclusions:
- Basilar invagination (BI) is associated with a higher cephalic index (CI).
- The study confirms the association between basilar invagination (BI) and brachycephaly.
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