Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional brain function in schizophrenia. I. A positron emission tomography study.

R E Gur, S M Resnick, A Alavi

    Archives of General Psychiatry
    |February 1, 1987
    PubMed
    Summary

    Schizophrenia patients show altered brain glucose metabolism, with lower overall activity and a steeper subcortical to cortical gradient compared to controls. Severity correlates with metabolic patterns, challenging the "hypofrontality" theory.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Novel variants and rare clinical presentations in MFN2-related Charcot-Marie-Tooth disease: Insights from 10 families.

    Revue neurologique·2026
    Same author

    A hybrid experimental-numerical framework for prestressed concrete bridge model validation and sensor placement optimization: a case study.

    Scientific reports·2026
    Same author

    Benchmarking distinguishable cluster methods to platinum standard CCSDT(Q) non-covalent interaction energies in the A24 dataset.

    The Journal of chemical physics·2025
    Same author

    On the applicability of CCSD(T) for dispersion interactions in large conjugated systems.

    The Journal of chemical physics·2025
    Same author

    The direct role of nuclear motion in spin-orbit coupling in strongly correlated spin systems.

    The Journal of chemical physics·2024
    Same author

    Exploring experiences of living with removable dentures-A scoping review of qualitative literature.

    Gerodontology·2024

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Medical Imaging

    Background:

    • Schizophrenia is a complex psychiatric disorder associated with neurobiological abnormalities.
    • Cerebral glucose metabolism, a key indicator of brain activity, is often studied in schizophrenia.
    • Previous research has suggested patterns like
    • hypofrontality
    • but findings are inconsistent.

    Purpose of the Study:

    • To investigate local cerebral glucose metabolism in unmedicated individuals with schizophrenia compared to healthy controls.
    • To analyze metabolic differences across cortical-subcortical, antero-posterior, and laterality dimensions.
    • To explore the relationship between illness severity and metabolic patterns.

    Main Methods:

    Related Experiment Videos

  • Positron emission tomography (PET) with 18-F-fluorodeoxyglucose (FDG) was used to measure local cerebral glucose metabolism.
  • 12 unmedicated patients with schizophrenia and 12 matched healthy controls participated.
  • Data were analyzed for absolute metabolic rates and region/whole-brain ratios, including lobar comparisons.

    • Main Results:

    • Subcortical metabolism was higher than cortical metabolism across all participants.
    • Schizophrenia patients exhibited lower cortical and subcortical metabolism compared to controls.
    • A steeper subcortical to cortical metabolic gradient was observed in patients.
    • Higher illness severity correlated with higher absolute metabolism and greater left-hemispheric metabolism.

    Conclusions:

    • The findings support the presence of cerebral dysfunction in schizophrenia.
    • Results do not support the widely cited
    • hypofrontality
    • hypothesis in this sample.
    • Further research into the cortical-subcortical dimension is warranted for understanding schizophrenia pathophysiology.