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Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
Published on: January 19, 2018
Recent advances of nanotechnology-based tumor vessel-targeting strategies
Dongjie Zhu1, Yang Li1, Zhengjia Zhang1
1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Abstract:
Tumor vessels can provide oxygen and nutrition for solid tumor tissue, create abnormal tumor microenvironment (TME), and play a vital role in the development, immune escape, metastasis and drug resistance of tumor. Tumor vessel-targeting therapy has become an important and promising direction in anti-tumor therapy, with the development of five anti-tumor therapeutic strategies, including vascular disruption, anti-angiogenesis, vascular blockade, vascular normalization and breaking immunosuppressive TME. However, the insufficient drug accumulation and severe side effects of vessel-targeting drugs limit their development in clinical application. Nanotechnology offers an excellent platform with flexible modified surface that can precisely deliver diverse cargoes, optimize efficacy, reduce side effects, and realize the combined therapy. Various nanomedicines (NMs) have been developed to target abnormal tumor vessels and specific TME to achieve more efficient vessel-targeting therapy. The article reviews tumor vascular abnormalities and the resulting abnormal microenvironment, the application of NMs in the tumor vessel-targeting strategies, and how NMs can improve these strategies and achieve multi-strategies combination to maximize anti-tumor effects.
Insights
Nanotechnology enhances tumor vessel-targeting therapies by improving drug delivery and reducing side effects. Nanomedicines offer a promising platform for combined anti-tumor strategies to maximize efficacy.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- Tumor vasculature is crucial for tumor growth, immune evasion, metastasis, and drug resistance.
- Current tumor vessel-targeting therapies face challenges like poor drug accumulation and significant side effects.
Purpose of the Study:
- To review tumor vascular abnormalities and their impact on the tumor microenvironment (TME).
- To explore the application of nanomedicines (NMs) in various tumor vessel-targeting strategies.
- To discuss how NMs can enhance these strategies and enable combination therapies for improved anti-tumor effects.
Main Methods:
- Review of existing literature on tumor vascular abnormalities.
- Analysis of nanomedicine applications in anti-angiogenesis, vascular disruption, blockade, normalization, and TME modulation.
- Evaluation of nanomedicine-based combination strategies for enhanced anti-tumor outcomes.
Main Results:
- Nanomedicines can precisely target abnormal tumor vessels and the TME.
- NMs improve drug accumulation, optimize efficacy, and reduce side effects of vessel-targeting agents.
- NMs facilitate combined therapeutic strategies for synergistic anti-tumor effects.
Conclusions:
- Nanotechnology provides a versatile platform for advanced tumor vessel-targeting therapies.
- Nanomedicines hold significant potential to overcome limitations of current strategies and improve clinical outcomes.
- Combined nanomedicine approaches offer a promising avenue for maximizing anti-tumor efficacy.
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