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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Depressants01:28

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Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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A-TAPER: A Framework for Deprescribing Medications effectively.

L T Armistead1, K A Sanders1, C K Larson2

  • 1UNC Eshelman School of Pharmacy, 301 Pharmacy Lane, Chapel Hill, NC, 27599-7574, USA.

Research in Social & Administrative Pharmacy : RSAP
|December 21, 2021
PubMed
Summary
This summary is machine-generated.

Deprescribing unnecessary medications in older adults is crucial for safety. A new A-TAPER framework guides providers in assessing, discussing, planning, engaging patients, and reducing medication doses effectively.

Keywords:
BenzodiazepinesDeprescribingMedication managementOpioids

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Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Patient Safety

Background:

  • Inappropriate medication use in older adults leads to preventable safety concerns.
  • Deprescribing high-risk or low-benefit medications is vital for reducing morbidity and adverse effects in this demographic.
  • Existing deprescribing resources lack a unified framework for practical implementation.

Purpose of the Study:

  • To present a novel, interprofessional framework for guiding healthcare providers in the deprescribing process.
  • To establish a structured approach for managing unnecessary medications in older adults.

Main Methods:

  • Development of the A-TAPER (Assess, Talk, Alternatives, Plan, Engage, Reduce) framework by an interprofessional team (pharmacists, geriatricians, researchers).
  • The framework provides a systematic guide for deprescribing medications.

Main Results:

  • The A-TAPER framework offers a singular, actionable approach to deprescribing.
  • This framework facilitates the creation of comprehensive, medication-specific deprescribing toolkits.

Conclusions:

  • The A-TAPER framework provides a structured, interprofessional approach to deprescribing in older adults.
  • Implementation of this framework can enhance medication safety and reduce adverse events in geriatric populations.