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Menetrier's disease exacerbating ulcerative colitis and relieved by gastrectomy
Tahrima Kayes1, Mark Bonnichsen2, Laura Willmann1
1Department of Gastroenterology and Hepatology, Liverpool Hospital, Liverpool, New South Wales, Australia.
BMJ Open Gastroenterology
|December 21, 2021
Summary
Ménétrier
Area of Science:
- Gastroenterology and Internal Medicine
- Rare Diseases and Conditions
Background:
- Ménétrier's disease (MD) is a rare gastropathy causing enlarged stomach folds and protein loss.
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
Observation:
- A 21-year-old woman presented with co-occurring MD and UC, complicating management due to overlapping symptoms and limited treatment options.
- The patient experienced persistent vomiting, hypoalbuminemia, and nutritional decline despite trials of octreotide, cetuximab, infliximab, and methotrexate.
Findings:
- Medical management for both MD and UC failed to resolve the patient's symptoms and hypoalbuminemia.
- Total gastrectomy was ultimately performed, leading to complete resolution of MD-associated symptoms and hypoalbuminemia.
Implications:
- This case highlights the diagnostic and therapeutic challenges in managing comorbid MD and UC.
- Total gastrectomy can be an effective, albeit radical, treatment for severe, refractory Ménétrier's disease with protein-losing gastropathy.
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