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[Basedow's disease and mitral valve prolapse].

G Kahaly, R Erbel, S Mohr-Kahaly

    Deutsche Medizinische Wochenschrift (1946)
    |February 13, 1987
    PubMed
    Summary
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    Is there a methimazole dose effect on remission rate in Graves' disease? Results from a long-term prospective study. The European Multicentre Trial Group of the Treatment of Hyperthyroidism with Antithyroid Drugs.

    Clinical endocrinology·1999

    Patients with Graves' disease have a significantly higher incidence of mitral valve prolapse (60%) compared to toxic nodular goitre (10%) and controls (9.9%). This suggests a potential autoimmune link in Graves' disease affecting the mitral valve.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Immunology

    Context:

    • Graves' disease is an autoimmune disorder affecting the thyroid.
    • Mitral valve prolapse (MVP) is a common valvular heart condition.
    • The association between Graves' disease and MVP requires further investigation.

    Purpose:

    • To investigate the prevalence of mitral valve prolapse in patients with Graves' disease and toxic nodular goitre.
    • To compare MVP incidence in these patient groups with a control population.
    • To explore potential links between MVP, thyroid disease, and human leukocyte antigen (HLA) phenotypes.

    Summary:

    • A study involving 60 Graves' disease patients, 20 toxic nodular goitre patients, and 2410 controls found a 60% MVP prevalence in Graves' disease, significantly higher than toxic nodular goitre (10%) and controls (9.9%).

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  • Mitral valve prolapse was defined as systolic buckling ≥3 mm via echocardiography.
  • Graves' disease patients also exhibited a higher incidence of thickened myxomatous valves (33.3%) compared to controls. HLA-B8 and HLA-DR3 were frequently observed in Graves' patients with MVP.

    • Impact:

    • Findings suggest a potential autoimmune mechanism contributing to mitral valve prolapse in Graves' disease.
    • Highlights the importance of echocardiographic screening for MVP in patients with Graves' disease, especially those with ophthalmopathy.
    • Provides evidence for a multi-organ autoimmune process in Graves' disease, involving the heart valve.