Tumor Microenvironment Responsive Single-Atom Nanozymes for Enhanced Antitumor Therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Materials Science

Background:

• Single-atom nanozymes (SAzymes) leverage the tumor microenvironment (TME) for targeted cancer therapy.
• SAzymes offer 100% metal atom utilization, enhancing enzyme-catalyzed therapeutic efficiency.
• They serve as precise models for investigating therapeutic mechanisms.

Purpose of the Study:

• To review synthetic strategies for SAzymes.
• To explore TME-responsive SAzyme activities and their antitumor applications.
• To outline future challenges and opportunities in SAzyme development for cancer therapy.

Main Methods:

• Review of existing literature on SAzyme synthesis and TME-responsive mechanisms.
• Summarization of enhanced antitumor therapeutic approaches utilizing SAzyme enzymatic activities.
• Elaboration on the underlying therapy mechanisms.

Main Results:

• SAzymes exhibit specific responses to TME features, enabling targeted therapy.
• TME-responsive SAzymes significantly enhance antitumor therapeutic efficacy.
• Detailed understanding of SAzyme-based therapy mechanisms is provided.

Conclusions:

• SAzymes represent a promising frontier in enhanced antitumor therapy.
• Further development in SAzyme design and engineering is crucial.
• This review offers guidance for future SAzyme research and applications.