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Related Concept Videos

Visual Agnosia01:12

Visual Agnosia

436
Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
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Related Experiment Video

Updated: Oct 9, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

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Anatomical and functional visual network patterns in progressive multiple sclerosis.

Yael Backner1,2, Sol Zamir1,2, Panayiota Petrou3

  • 1The fMRI Unit, Department of Neurology, Hadassah Medical Organization, Jerusalem, Israel.

Human Brain Mapping
|December 21, 2021
PubMed
Summary
This summary is machine-generated.

Even years after optic neuritis, progressive multiple sclerosis patients show reduced brain network efficiency. This suggests the brain

Keywords:
DTIfMRImultiple sclerosisoptic neuritisplasticityvisual cortex

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Progressive multiple sclerosis (MS) is characterized by accumulating disability, potentially linked to neurodegeneration and impaired brain adaptability.
  • Optic neuritis is a common early symptom in MS, but its long-term impact on visual network structure and function in progressive MS is not fully understood.

Purpose of the Study:

  • To investigate if structural and functional visual network changes persist in progressive MS patients years after optic neuritis.
  • To explore the relationship between past optic neuritis, brain network integrity, and the brain's adaptive capacity in progressive MS.

Main Methods:

  • Structural and functional MRI (including diffusion tensor imaging and resting-state fMRI) were performed on 48 progressive MS patients.
  • Patients were divided into groups with (n=21) and without (n=27) a history of optic neuritis.
  • Graph theory-based methods were used to analyze anatomical and functional visual networks.

Main Results:

  • Patients with a history of optic neuritis exhibited significantly lower anatomical global efficiency and network density compared to those without.
  • No significant differences in functional network metrics were observed between the groups.
  • Lesion load did not significantly differ between the optic neuritis and non-optic neuritis groups, suggesting distal damage effects.

Conclusions:

  • Long-standing optic nerve damage from optic neuritis can lead to trans-synaptic effects impacting visual network structure in progressive MS.
  • The brain's capacity for early adaptation or compensation may be altered or diminished in these patients.
  • Reduced brain compensation ability is a critical factor to consider when explaining progressive disability accumulation in MS.