Flash Electrochemical Approach to Carbocations
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Updated: Oct 9, 2025

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals
Published on: May 29, 2018
Masahiro Takumi1, Hodaka Sakaue1, Aiichiro Nagaki1
1Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigakukatsura Nishikyo-ku, Kyoto, 615-8510, Japan.
Abstract:
A novel flow electrochemical reactor that accomplishes electrolysis within a few seconds in a single passage was developed. By using the flow reactor system, the flash electrochemical generation of short-lived carbocations, including oxocarbenium ions, N-acyliminium ions, glycosyl cations, and Ferrier cations was achieved within a few seconds, enabling the subsequent reaction with nucleophiles before their decomposition. Moreover, continuous operation based on the present system enabled the rapid synthesis of pharmaceutical precursors on demand.
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