Related Experiment Video
Updated: Oct 9, 2025
Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and
Yvan Courageux1,2, Marta Monguió-Tortajada1,2,3, Cristina Prat-Vidal1,2,3,4
1ICREC Research Program, Health Science Research Institute Germans Trias i Pujol, Badalona, Spain.
Abstract:
The present paper is a commentary to 'Identification and characterization of hADSC-derived exosome proteins from different isolation methods' (Huang et al. 2021; 10.1111/jcmm.16775). Given the enthusiasm for the potential of mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs), some considerations deserve attention as they move through successive stages of research and application into humans. We herein remark the prerequisite of generating that evidence ensuring a high consistency in safety, composition and biological activity of the intended MSC-EV preparations, and the suitability of disparate isolation techniques to produce efficacious EV preparations and fulfil requirements for standardized clinical-grade biomanufacturing.
