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Updated: Oct 9, 2025

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Cesarean delivery is associated with suppressed activities of the stress axes

Cihat Uçar1, Mehmet Bülbül2, Sedat Yıldız3

  • 1Department of Physiology, Faculty of Medicine, University of Adıyaman, Adıyaman, Turkey.

Stress (Amsterdam, Netherlands)
|December 21, 2021
PubMed

Maternal pre- and post-delivery stress levels might be different for vaginal or cesarean deliveries. This study aimed to investigate the effects of type of delivery (vaginal or cesarean) and time of delivery (pre- and post-delivery) on the stress axes of the body, namely the hypothalamic-pituitary adrenal axis (HPA) and autonomic nervous system (ANS).Ninety-one pregnant women were volunteered to participate this prospective study. In these women, pre- and post-delivery HPA and ANS activities were measured noninvasively by salivary cortisol and heart rate variability (HRV), respectively. HRV was measured by 5-min electrocardiogram recording and time- and frequency-domain parameters were computed.Salivary cortisol concentration and HRV parameters were higher in women having vaginal delivery than those having cesarean delivery (p < 0.05). Cortisol levels did not differ between pre- and post-delivery (p > 0.05) but the time-domain parameters of HRV decreased post-delivery (p < 0.05). No interactions were observed between the types and times of delivery (p > 0.05).HPA and ANS axes had different activity patterns throughout the delivery process and they were higher during vaginal delivery, suggesting that they are integral parts of normal birth process and that cesarean delivery perturbs the activity of both axes.

Keywords:
Cortisolcesarean deliverydelivery timedelivery typeheart rate variabilityvaginal delivery

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