Selective RF excitation designs enabled by time-varying spatially non-linear ΔB₀ fields with applications in fetal...

To demonstrate, through numerical simulations, novel designs of spatially selective radiofrequency (RF) excitations of the fetal brain by both a restricted 2D slice and 3D inner-volume selection. These designs exploit a single-channel RF pulse, conventional gradient fields, and the spatially non-linear ΔB₀ fields of a multi-coil shim array, using an auto-differentiation optimization algorithm.

The design algorithm jointly optimizes the RF pulse and the time-varying ΔB₀ fields, which is produced by a 64-channel multi-coil ΔB₀ body array to augment the RF and the linear gradient fields, using an auto-differentiation approach. Two design targets were specified, one a 4-mm thick slice with a limited in-slice extent in one dimension ("restricted slice"), and the other a 3D inner-volume selection encompassing the fetal brain ("inner volume"). The RF duration was limited to 2 ms for the restricted slice excitation and 6 ms for the inner-volume excitation.

Excitation profiles were achieved for both the restricted slice excitation task (one-minus-minimum magnitude, 8%) within the region of interest (ROI) and (maximum-minus-zero magnitude, 8%) in the suppressed regions and the fetal brain volume excitation task (13% and 9%, respectively).

The proposed joint design of RF and time-varying, spatially non-linear ΔB₀ fields achieves the target excitation profiles with short RF pulse durations and demonstrates the potential to enhance fetal MRI with multi-channel body shim arrays.