How Diverse Is Medicinal Chemistry? Insights into Race, Ethnicity, Origin, Gender, and Geography

Richard J D Hatley1, Steve P McLachlan2, Kathleen Baster3

  • 1RGDscience Ltd, 2nd Floor, 2 Walsworth Road, Hitchin, Herts SG4 9SP, United Kingdom.

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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