Related Experiment Video

Updated: Oct 9, 2025

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

2.0K

COVID-19 Vaccination in Children: An Open Question

Giuseppe Campagnani1, Flaminia Bardanzellu1, Maria Cristina Pintus1

  • 1Department of Surgical Sciences, Neonatal Intensive Care Unit, AOU University of Cagliari, Cagliari, Italy, SS 554 km 4,500, 09042 Monserrato, CA , Italy.

Current Pediatric Reviews
|December 21, 2021
PubMed

Insights

COVID-19 vaccination for children and adolescents is recommended, though further research is needed to confirm vaccine-related side effects. This review examines the pros and cons of pediatric COVID-19 immunization.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Public Health

Background:

  • The COVID-19 pandemic necessitates effective control measures, with vaccines being paramount.
  • While children face lower severe disease risk, pediatric vaccination can curb community viral spread.
  • High safety standards are crucial for vaccines administered to healthy pediatric populations.

Purpose of the Study:

  • To conduct a narrative review of current literature on the benefits and drawbacks of COVID-19 vaccination in children and adolescents.
  • To analyze the available data regarding the efficacy and safety of COVID-19 vaccines in the pediatric demographic.

Main Methods:

  • Bibliographic research was performed using PubMed, Read, and Scopus databases.
  • Keywords included "COVID-19", "SARS-CoV-2", "immunization", "antibody", "COVID-19 vaccine efficacy", "COVID-19 vaccine safety", "children", "adolescents", "MIS-C", and "adverse effects".

Main Results:

  • Children, while less susceptible, can develop severe outcomes like multi-inflammatory syndrome.
  • Adverse effects post-vaccination in adolescents and young adults are reported but appear to be isolated cases.
  • Thorough evaluation of vaccine-related side effects is essential before pediatric administration.

Conclusions:

  • Further investigation is required to establish causality between COVID-19 vaccines and adverse effects.
  • COVID-19 vaccination is currently recommended for individuals aged 12 and older.
  • The debate surrounding pediatric vaccination involves complex ethical, political, and social considerations.
Abstract

Keywords:
COVID-19COVID-19 vaccine efficacyCOVID-19 vaccine safetyMIS-CSARS-CoV-2adolescentsadverse effectsantibodychildrenimmunization

More Related Videos

Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children06:22

Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children

Published on: February 10, 2023

1.1K
Oral Biofilm Sampling for Microbiome Analysis in Healthy Children10:42

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

17.4K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
45.8K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
28
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
15
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
24
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
15
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
17