[The decrease in procoagulant activity of blood during combined therapy with antidepressants and antipsychotics in
O S Brusov1, N S Karpova1, I V Oleichik1
1Mental Health Research Center, Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|December 21, 2021
Summary
Combined antipsychotic and antidepressant treatment significantly reduced inflammation markers in patients with endogenous mental disorders. Antipsychotics alone did not show the same anti-inflammatory effects, suggesting a synergistic benefit.
Area of Science:
- Neuroscience
- Psychiatry
- Hematology
Background:
- Endogenous mental disorders are associated with systemic inflammation.
- Thrombodynamics indices reflect coagulation and inflammation.
- Treatment efficacy in mental health can be influenced by inflammatory processes.
Purpose of the Study:
- To compare thrombodynamics indices in patients with endogenous mental disorders before and after treatment.
- To evaluate the impact of combined antipsychotic and antidepressant therapy versus antipsychotics alone.
Main Methods:
- 110 patients (aged 16-60) with schizophrenia, schizotypal disorder, or affective disorder were studied.
- Thrombodynamics tests were performed using a T-2 thrombodynamics device.
- Patients were divided into two groups: combined therapy (AD + group) and antipsychotics only (AD- group).
Main Results:
- Combined therapy (antipsychotics + antidepressants) significantly decreased plasma procoagulant activity and spontaneous clot formation.
- This decrease suggests a reduction in systemic and immune inflammation in the AD + group.
- Antipsychotic monotherapy showed no significant decrease in these thrombodynamics parameters, indicating persistent inflammation.
Conclusions:
- Combined antipsychotic and antidepressant treatment positively impacts plasma and platelet hemostasis.
- This suggests a potential biological, pathogenetic link for augmenting antipsychotic therapy.
- The findings highlight the benefit of adding antidepressants to antipsychotics for managing inflammation in endogenous mental disorders.
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