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Updated: Oct 9, 2025

New Methods to Study Gustatory Coding
Published on: June 29, 2017
Multiple interaction modes between saccharin and sweet taste receptors determine a species-dependent response to
Xiangzhong Zhao1, Meng Liu1, Meng Cui2
1Department of Food Science and Engineering, Qilu University of Technology, Jinan, China.
Abstract:
Saccharin is a commonly used artificial sweetener that exhibits both sweetening and sweet inhibition activities. The species-dependent response towards saccharin and the interaction between saccharin and the sweet taste receptor T1R2/T1R3 remain elusive. In this study we used mismatched chimeras of T1R2 and T1R3 and calcium mobilization functional analysis to reveal a detailed species-dependent response towards saccharin of human, squirrel monkey, and mouse sweet taste receptors. Our findings, combined with previous results by others, suggest multiple and complex interaction modes between saccharin and the sweet taste receptor, which are helpful guidelines for effective modulation of the sweet taste by sweetener/sweet inhibitors.
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