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Developing a morphomics framework to optimize implant site-specific design parameters for islet macroencapsulation

Barry McDermott1, Scott Robinson2,3,4, Sven Holcombe3

  • 1Translational Medical Device Lab, College of Medicine Nursing and Health Sciences, National University of Ireland (NUI) Galway, Galway, Ireland.

Journal of the Royal Society, Interface
|December 21, 2021
PubMed
Summary
This summary is machine-generated.

Designing effective cell macroencapsulation devices for Type 1 diabetes requires understanding anatomy. The posterior rectus sheath offers a promising site, enabling optimized elliptical device designs for impactful cell delivery.

Keywords:
beta-cell transplantationimplant siteislet transplantationmacroencapsulation devicemorphomics

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Cell macroencapsulation is crucial for Type 1 diabetes treatment, but delivering sufficient cell numbers remains a challenge.
  • Optimizing device design requires understanding anatomical implant sites for practicality and cell survival.
  • The posterior rectus sheath plane is proposed as a suitable site due to accessibility and potential for nutritive support.

Purpose of the Study:

  • To identify and evaluate the posterior rectus sheath plane as a potential anatomical site for cell macroencapsulation devices.
  • To determine optimal device shapes for maximizing cell dose within anatomical constraints.
  • To inform the design of future macroencapsulation devices for improved clinical impact in Type 1 diabetes.

Main Methods:

  • Morphomics analysis of a cohort of 642 participants, stratified by gender, age, and BMI.
  • Shape optimization techniques to maximize implantable volume within the identified anatomical space.
  • Evaluation of elliptical device designs for their potential to achieve clinically relevant cell doses.

Main Results:

  • The posterior rectus sheath plane was identified as a viable anatomical site for cell macroencapsulation.
  • Morphomics data analysis informed the optimization of device dimensions and shapes.
  • Elliptical device designs were found to achieve a clinically impactful cell dose while meeting manufacturing and delivery requirements.

Conclusions:

  • The posterior rectus sheath plane presents a favorable anatomical site for cell macroencapsulation device implantation.
  • A morphomics-driven, shape optimization approach can significantly enhance the design of cell macroencapsulation devices.
  • This framework has the potential to improve the efficacy of cell-based therapies for Type 1 diabetes.