Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats

Area of Science:

• Biomedical Science
• Pharmacology
• Reproductive Biology

Background:

• Preeclampsia (PE) is a serious pregnancy complication characterized by hypertension and proteinuria.
• Lipopolysaccharide (LPS) can induce a PE-like condition in animal models, aiding research into disease mechanisms.
• Fisetin, a natural flavonoid, has shown anti-inflammatory and antioxidant properties in various studies.

Purpose of the Study:

• To investigate the therapeutic function of Fisetin in a lipopolysaccharide (LPS)-induced preeclampsia (PE) rat model.
• To elucidate the underlying molecular mechanisms of Fisetin's action in PE.

Main Methods:

• Establishment of an LPS-induced PE-like rat model.
• In vivo administration of Fisetin to assess its effects on PE.
• Analysis of biochemical markers, placental and fetal parameters, and key signaling pathways (TLR4/NF-κB and Nrf2/HO-1).

Main Results:

• Fisetin treatment significantly reduced hypertension, proteinuria, and inflammatory markers (TNF-α, IL-6, IL-1β) in PE rats.
• Fisetin administration improved placental and fetal weight, and enhanced antioxidant capacity (GSH, SOD).
• Fisetin suppressed the TLR4/NF-κB pathway and promoted the Nrf2/HO-1 pathway in placental tissues.

Conclusions:

• Fisetin exerts a protective role in LPS-induced preeclampsia-like rat models.
• Fisetin modulates the activation of the TLR4/NF-κB and Nrf2/HO-1 signaling pathways.
• These findings suggest Fisetin as a potential therapeutic agent for preeclampsia.