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Updated: Oct 9, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity
V Basavanna1, M Chandramouli1, C Kempaiah2
1Department of Chemistry, Vidyavardhaka College of Engineering, Visvesvaraya Technological University, Mysore, 570002 Karnataka, India.
Abstract:
A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, 1H and 13C NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.
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