Epithelioid Variant of Pleomorphic Liposarcoma: A Rare Challenging Diagnosis Causing Severe Medial Thigh Pain

We present the case of pleiomorphic liposarcoma in the medial compartment of the thigh of a 59-year-old female patient. The lump was noticed eight months prior to presentation and had gradually increased in size, leading to pressure symptoms in her thigh. Although painless initially, the lump eventually became tender prompting her to seek surgical attention. At the plastic surgery clinic, she was advised to get an MRI, which revealed an irregular but well-defined mass lesion measuring 8.2 x 6.6 x 4.3 cm. The mass did not have any manifestations in the surrounding structures. A wide excisional biopsy was then performed, and multiple sections were processed for histopathological analysis, confirming a diagnosis of epithelioid variant of pleomorphic liposarcoma.