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Thyroiditis After COVID-19 mRNA Vaccine: A Case Series
Manthan Pandya1, Geethika Thota2, Xiangbing Wang1
1Division of Endocrinology, Robert Wood Johnson University Hospital, New Brunswick, New Jersey.
AACE Clinical Case Reports
|December 22, 2021
Summary
COVID-19 mRNA vaccines may trigger thyroiditis with thyrotoxicosis in some individuals. This condition, characterized by inflammation and overactive thyroid, warrants further investigation and recognition by healthcare providers.
Area of Science:
- Endocrinology
- Immunology
- Vaccinology
Background:
- Subacute thyroiditis has been linked to SARS-CoV-2 infection.
- The COVID-19 mRNA vaccines are increasingly suspected of inducing thyroiditis, presenting with thyrotoxicosis.
Observation:
- Three patients without prior thyroid disease developed symptomatic thyroiditis with thyrotoxicosis 10-20 days post-vaccination with mRNA COVID-19 vaccines.
- Thyrotoxicosis was confirmed biochemically and radiologically, with negative tests for Graves' disease and no autonomous nodules.
- Elevated inflammatory markers, including erythrocyte sedimentation rate and interleukin-6, were noted in one patient.
Findings:
- The COVID-19 mRNA vaccine was associated with the development of thyroiditis and subsequent thyrotoxicosis.
- Inflammatory markers and cytokines may play a significant role in vaccine-induced thyroid dysfunction.
Implications:
- This case series suggests a potential link between COVID-19 mRNA vaccination and thyroiditis with thyrotoxicosis.
- Healthcare providers should be aware of this possible adverse effect for prompt diagnosis and management.
- Further research is needed to elucidate the mechanisms and prevalence of vaccine-associated thyroiditis.
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