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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

A single base mutation in an I-A alpha-chain gene alters T-cell recognition

I J Griffith, E M Choi, L H Glimcher

    Proceedings of the National Academy of Sciences of the United States of America
    |February 1, 1987
    PubMed
    Summary

    Researchers investigated the I-Ak alpha-chain molecule to understand T-cell antigen receptor interactions. A specific mutation at amino acid 75 impacts Ia molecule function in antigen presentation.

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