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Updated: Oct 9, 2025
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Impact of an online multicomponent very-low-carbohydrate program in women with polycystic ovary syndrome: a pilot
Amanda L Missel1, Alison Virginia O'Brien1, Haley Maser2
1Department of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, Michigan.
Objective:
To study the impact of a very-low-carbohydrate (VLC) diet for 16 weeks in overweight or obese women with polycystic ovary syndrome (PCOS).
Design:
Single-arm prospective pilot study.
Setting:
We recruited participants using medical records from an academic medical center.
Patients:
Twenty-nine overweight or obese women (body mass index, 25-50 kg/m2) with PCOS.
Interventions:
We taught participants to follow a VLC diet and provided information about a variety of behavioral skills including mindfulness and positive affect using an online 16-week intervention.
Main Outcome Measures:
Changes in body weight, glycated hemoglobin, and PCOS-related quality of life.
Results:
The intervention led to positive health outcomes including decreases in percent weight (mean difference = -7.67, SD = 6.10) and glycated hemoglobin level (mean difference = -0.21%, SD = 0.27), an increase in sex hormone binding globulin level (mean difference = 9.24 nmol/L, SD = 16.34), and increases in PCOS-related quality of life measures, including menstrual predictability (mean difference = 2.10, SD = 2.76) and body hair (mean difference = 1.14, SD = 1.04). The low-density lipoprotein cholesterol level increased (mean difference = 0.23 mmol/L, SD = 0.49).
Conclusions:
The results suggest that a VLC dietary intervention has potential to promote both weight loss and glycemic control in overweight and obese adults with PCOS, two key components in the prevention of type 2 diabetes.
Trial Registration Number:
NCT03987854.
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