Spontaneous ovarian hyperstimulation syndrome in a pregnant woman with hypothyroidism: a case report

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Fertility Preservation in Patients with Severe Ovarian Dysfunction

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Lucas Oliveira E Souza¹, João Vitor Innecco Arêas¹, Maria Clara Rezende Campos¹

¹Department of Medicine, Minas Gerais Faculty of Medical Sciences, Belo Horizonte, Brazil.

|December 22, 2021

Abstract

Objective:

To study a rare case of spontaneous ovarian hyperstimulation syndrome in a naturally conceived pregnancy associated with overt hypothyroidism.

Design:

Case report.

Setting:

Endocrinology private practice.

Patients:

A 32-year-old woman who was 13 weeks pregnant with bilaterally enlarged ovaries presumed to be secondary to hypothyroidism.

Interventions:

Administration of levothyroxine and titration of the dose.

Main Outcome Measures:

Regression of signs and symptoms of spontaneous ovarian hyperstimulation syndrome after 12 weeks of therapy.

Results:

The patient was diagnosed with severe hypothyroidism, as confirmed by her elevated thyroid-stimulating hormone level. Ultrasound evaluation revealed ovarian enlargement secondary to multiple contiguous cysts with anechoic content. The patient was administered levothyroxine 175 μg/day. Results of hormonal studies demonstrated thyroid function normality at week 12 after treatment. Incomplete regression of ovarian cysts was also noticed within this period. At week 37, the patient developed preeclampsia, and cesarean delivery was recommended. An 8-month postpartum ultrasound evaluation revealed complete regression of the cysts.

Conclusions:

Spontaneous ovarian hyperstimulation syndrome secondary to hypothyroidism may be the cause of ovarian enlargement, and levothyroxine replacement seems an appropriate primary therapeutic option. Proper endocrinological assessment of patients is recommended as it may avoid unfavorable outcomes.

Keywords:

Hypothyroidism ovarian cysts pregnancy spontaneous ovarian hyperstimulation

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