Advances in endocrine toxicity of nanomaterials and mechanism in hormone secretion disorders

The size of nanoparticles is about 1-100 nm. People are exposed to nanoparticles in environmental pollutants from ancient times to the present. With the maturity of nanotechnology in the past two decades, the production of manufactured nanomaterials is rapidly increasing and they are used in a wide range of aerospace, medicine, food, and industrial applications. However, both natural and manufactured nanomaterials have been proved to pose a threat to diverse organs and systems. The endocrine system is critical to maintaining homeostasis. Endocrine disorders are associated with many diseases, including cancer, reduced fertility, and metabolic diseases. Therefore, we review the literatures dealing with the endocrine toxicity of nanomaterial. This review provides an exhaustive description of toxic effects of several common nanomaterials in the endocrine system; more involved are reproductive endocrinology. Then physicochemical factors that determine the endocrine toxicity of nanomaterials are discussed. Furthermore, oxidative stress, changes in steroid production and metabolic enzymes, organelle disruption, and alterations in signal pathways are introduced as potential mechanisms that may cause changes in hormone levels. Finally, we suggest that a risk assessment of endocrine toxicity based on standard procedures and consideration of endocrine disrupting effects of nanomaterials in the field and its environmental and population effects could be future research directions for endocrine toxicity of nanomaterials.