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Testicular Lesions in Infertile Men
Margot Dupeux1,2, Florian Maxwell3, Laurence Rocher3,4,5
1Department of Pathology, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
American Journal of Clinical Pathology
|December 22, 2021
Summary
Frozen section examination (FSE) accurately identifies Leydig cell tumors in incidental testicular tumors found during infertility workups. However, FSE is unreliable for fibrous lesions, which may indicate regressed tumors.
Area of Science:
- Urology
- Pathology
- Reproductive Medicine
Background:
- Incidental testicular tumors are increasingly diagnosed during infertility evaluations.
- Accurate intraoperative diagnosis is crucial for appropriate management.
Purpose of the Study:
- To evaluate the diagnostic accuracy of frozen section examination (FSE) for incidental testicular tumors.
- To assess the reliability of FSE in guiding the management of these tumors.
Main Methods:
- Retrospective analysis of 46 testicular tumors.
- Tumors were diagnosed during infertility workup between 2000 and 2019.
- All tumors were evaluated using frozen section examination (FSE).
Main Results:
- FSE correctly diagnosed malignancy in 23 cases, with 22 confirmed on final pathology.
- FSE accurately identified benign Leydig cell tumors (11 cases) and hyperplasias (2 cases).
- FSE showed low reliability for fibrous lesions (10 cases), 6 of which were associated with malignancy.
Conclusions:
- Frozen section examination (FSE) is valuable for diagnosing Leydig cell tumors found incidentally during infertility workups.
- FSE is not reliable for diagnosing fibrous lesions, which may represent regressed testicular tumors and require careful consideration.
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