Research Progress on the Correlation Between Vitamin D and Neurological Disorders

Area of Science:

• Neurology
• Endocrinology
• Nutritional Neuroscience

Background:

• Vitamin D (VD) deficiency is prevalent globally.
• VD acts as a neuroactive steroid, crucial for central nervous system protection.
• Neurological disorders such as stroke and epilepsy are significant public health concerns.

Purpose of the Study:

• To review the correlation between vitamin D and neurological disorders.
• To explore the potential of VD as a therapeutic agent for neurological conditions.
• To provide insights for future research and clinical applications of VD.

Main Methods:

• Systematic literature search of PubMed and Embase databases (2010-2021).
• Keywords included vitamin D, 1,25-dihydroxyvitamin D3, stroke, epilepsy, and cognitive dysfunction.
• Inclusion criteria focused on study design, sample selection, intervention, control measures, and statistical significance (OR, 95% CI).

Main Results:

• An initial search yielded 1,360 articles; 81 were included in the final analysis.
• A significant portion (76 articles) were published within the last five years, indicating recent research interest.
• The included studies highlight the association between VD deficiency and various neurological diseases.

Conclusions:

• VD deficiency is widespread and associated with multiple neurological diseases.
• VD plays a vital role in protecting the central nervous system.
• VD holds potential for the comprehensive treatment of neurological disorders, including stroke and epilepsy, by influencing cognitive function.