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Recent Evidence and Possible Therapy against COVID-19-Mediated Hepatic Dysfunction
1Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh 11451, Saudi Arabia.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, leading to liver injury. This review explores COVID-19
Area of Science:
- Virology
- Hepatology
- Immunology
Background:
- Emergence of novel RNA coronavirus, SARS-CoV-2, causing COVID-19.
- Hepatic injury is a significant complication with multifactorial causes.
- Mechanisms of infection-mediated liver injury remain poorly understood.
Purpose of the Study:
- To review probable mechanisms of COVID-19-associated hepatic dysfunction.
- To discuss therapeutic options for COVID-19 and liver injury.
- To analyze prescribed medications for COVID-19.
Main Methods:
- Literature review focusing on COVID-19 and hepatic dysfunction.
- Analysis of reported cases and biochemical alterations.
- Examination of viral load, inflammation, and drug toxicity in liver injury.
Main Results:
- COVID-19 often presents with pulmonary issues but can cause systemic infection affecting the liver.
- A significant proportion of COVID-19 patients exhibit liver damage or dysfunction.
- Altered liver enzyme biochemistry is frequently observed in COVID-19 patients.
Conclusions:
- COVID-19 can lead to significant hepatic dysfunction through various mechanisms.
- Understanding these mechanisms is crucial for effective patient management.
- A range of therapeutic strategies, including antivirals and immune-based therapies, are being investigated.
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