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A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
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Quantitative Surface-Enhanced Spectroscopy.

Ryan D Norton1, Hoa T Phan1, Stephanie N Gibbons1

  • 1Department of Chemistry, University of Iowa, Iowa City, Iowa, USA;

Annual Review of Physical Chemistry
|December 22, 2021
PubMed
Summary
This summary is machine-generated.

Surface-enhanced Raman scattering (SERS) offers powerful trace molecular detection. This review details advances in quantitative SERS by examining intermolecular interactions, surface rules, and molecule accessibility for improved reproducibility.

Keywords:
SERSintermolecular interactionsquantitative detectionsurface selection rulessurface-enhanced Raman scattering

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Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Nanotechnology

Background:

  • Surface-enhanced Raman scattering (SERS) is a sensitive technique for detecting trace molecules.
  • SERS relies on chemical and electromagnetic enhancements for signal amplification.
  • Recent advancements have improved SERS utility, reproducibility, and quantification, yet challenges remain.

Purpose of the Study:

  • To review and discuss advances in quantitative SERS detection.
  • To explore the influence of intermolecular interactions, surface selection rules, and molecule properties on SERS.
  • To outline successful quantitative SERS applications and future directions.

Main Methods:

  • Discussion of Raman scattering and SERS principles.
  • Analysis of surface selection rules and enhancement mechanisms impacting SERS observations.
  • Summary of experimental conditions for optimizing molecular affinity and density on SERS substrates.

Main Results:

  • Elucidation of how intermolecular interactions and surface selection rules affect SERS signal activation/deactivation.
  • Identification of key experimental parameters for tuning molecular interactions with SERS substrates.
  • Presentation of successful examples demonstrating quantitative SERS detection capabilities.

Conclusions:

  • Quantitative SERS detection is significantly influenced by molecular interactions and substrate properties.
  • Optimizing experimental conditions is crucial for enhancing the accuracy and reproducibility of SERS measurements.
  • Further research opportunities exist for advancing quantitative SERS applications.