A census of the lung: CellCards from LungMAP.

Area of Science:

• Pulmonary Biology
• Cellular and Molecular Medicine

Background:

• The human lung is crucial for respiration and host defense.
• Recent advances in single-cell RNA sequencing and genetic lineage tracing have uncovered new lung cell types and functions.
• A comprehensive understanding of lung cell diversity is needed.

Purpose of the Study:

• To create a practical cellular census of the normal human lung.
• To consolidate current knowledge on lung cell types, their functions, markers, and developmental origins.
• To establish a foundational resource for lung research.

Main Methods:

• Synthesis of existing data from the NHLBI-funded LungMAP Consortium and lung biology experts.
• Development of individual 'cell cards' detailing cell characteristics.
• Creation of a live, online guide for lung research.

Main Results:

• A comprehensive catalog of cell types in the normal lung.
• Detailed information on cell function, markers, developmental lineages, heterogeneity, regenerative potential, and disease associations.
• A publicly accessible online resource (https://www.lungmap.net/cell-cards/) for lung researchers.

Conclusions:

• The Lung CellCards provide a vital starting point for understanding lung cellular composition.
• This resource will facilitate community-wide efforts in lung research.
• The initiative aims to support the establishment, maintenance, and restoration of respiratory health.