Related Experiment Video

Updated: Oct 9, 2025

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
08:32

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Published on: March 1, 2015

21.5K

Swallowing Dynamics and Breathing-Swallowing Coordination Are Altered in Patients with Mild Cognitive Impairment

Yoshitaka Oku1,2, Naomi Yagi1,3, Madoka Nishino4

  • 1Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.

Dementia and Geriatric Cognitive Disorders
|December 22, 2021
PubMed
Abstract

Insights

Mild cognitive impairment (MCI) patients show delayed swallowing timing and prolonged laryngeal elevation during breathing-swallowing coordination. This indicates an early decline in these crucial functions even at the MCI stage.

Area of Science:

  • Neurology
  • Gerontology
  • Speech and Hearing Science

Background:

  • Swallowing requires precise laryngeal closure to prevent aspiration.
  • Reduced postinspiratory activity in a mouse model of tauopathy suggests potential swallowing deficits in related human conditions.
  • Mild cognitive impairment (MCI) may impact swallowing dynamics and breathing-swallowing coordination.

Purpose of the Study:

  • To investigate alterations in swallowing dynamics and breathing-swallowing coordination in patients with mild cognitive impairment (MCI).

Main Methods:

  • Breathing-swallowing coordination was assessed in MCI patients and an age-matched elderly cohort.
  • Utilized a respiratory flow sensor and a piezoelectric sensor on the neck.
  • Included patients meeting MCI criteria (MMSE ≥24, MoCA-J <26) and assessed with the Eating Assessment Tool.

Main Results:

  • MCI patients exhibited significantly delayed swallowing timing within the respiratory cycle.
  • Laryngeal elevation onset to peak time and duration were significantly prolonged in MCI patients.
  • No significant difference in the frequency of swallowing during or immediately after inspiration was observed between groups.

Conclusions:

  • Breathing-swallowing coordination begins to decline at the mild cognitive impairment (MCI) stage.
  • MCI is associated with altered timing and duration of laryngeal movements during swallowing.
  • Early detection of these swallowing changes may be crucial for managing MCI.
Keywords:
Breathing-swallowing coordinationMild cognitive impairmentSwallowing dynamics

More Related Videos

Minimally Invasive Murine Laryngoscopy for Close&#45;Up Imaging of Laryngeal Motion During Breathing and Swallowing07:22

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Published on: December 1, 2023

695
Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing14:13

Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing

Published on: May 6, 2014

18.4K

Related Concept Videos

Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
1.2K
Alterations in Respiration II01:30

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.1K
Deglutition01:25

Deglutition

Swallowing, otherwise known as deglutition, facilitates the transport of food from the mouth to the stomach. It is a multifaceted process that involves both the tongue and the muscles of the throat and esophagus. Saliva and mucus aid in this process, which takes approximately 4 to 8 seconds for semi-solid or solid food and around 1 second for liquids or very soft food.
Swallowing can be divided into three stages: the voluntary phase, the pharyngeal phase, and the esophageal phase. Although the...
2.8K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
361
Physical Assessment of the Respiratory Tract II: Inspection01:27

Physical Assessment of the Respiratory Tract II: Inspection

Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration...
453
Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
4.4K