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Consensus guidelines for antifungal stewardship, surveillance and infection prevention, 2021

Anna Khanina1,2, Shio Yen Tio1,2, Michelle R Ananda-Rajah3,4

  • 1National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Internal Medicine Journal
|December 22, 2021
PubMed

Insights

Antifungal stewardship (AFS) programs are crucial for managing invasive fungal diseases (IFD) in at-risk patients. These guidelines provide essential components and interventions to optimize antifungal use and improve patient outcomes.

Area of Science:

  • Infectious Diseases
  • Clinical Pharmacy
  • Public Health

Background:

  • Invasive fungal diseases (IFD) pose a significant mortality risk, especially in immunocompromised individuals.
  • Antifungal agent use leads to high healthcare costs, adverse drug reactions, drug interactions, and antifungal resistance.
  • Growing at-risk populations necessitate robust antifungal stewardship (AFS) programs.

Purpose of the Study:

  • To provide guidelines for implementing AFS programs.
  • To optimize antifungal prescribing and IFD management.
  • To detail quality processes for IFD prevention and surveillance.

Main Methods:

  • Outlines essential components, key interventions, and metrics for AFS programs.
  • Provides specific recommendations for IFD prevention during outbreaks, hospital construction, and for Candida auris.
  • Details IFD surveillance implementation for outbreak detection and intervention evaluation.

Main Results:

  • Establishes a framework for effective AFS program implementation.
  • Offers targeted strategies for IFD prevention and management in various clinical scenarios.
  • Highlights areas requiring further research in antifungal stewardship and IFD control.

Conclusions:

  • AFS programs are vital for controlling IFD and mitigating associated risks.
  • Structured guidelines and surveillance enhance IFD prevention and management efficacy.
  • Continued research is needed to address knowledge gaps in antifungal stewardship.
Keywords:
antifungal stewardshiphospital building workinfection preventioninvasive fungal diseaseoutbreak managementquality process

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