Serum protein polymorphism in Bali (Indonesia).

Area of Science:

• Human genetics
• Population genetics
• Biochemistry

Background:

• Serum protein polymorphisms are valuable markers for population genetic studies.
• Understanding genetic diversity across different ethnic groups provides insights into human migration and adaptation.

Purpose of the Study:

• To investigate the genetic polymorphism of Gc, Pi, Tf, and Hp proteins in Balinese ethnic groups.
• To compare genetic diversity between distinct ethnic groups and an isolated village community in Bali.
• To discuss the anthropological implications of the observed genetic data.

Main Methods:

• Serum samples were collected from three ethnic groups and one isolated village in Bali.
• Isoelectric focusing electrophoresis was employed for Gc, Pi, Tf, and Hp subtyping.
• Allele frequencies and genetic diversity were analyzed.

Main Results:

• Gc system: Gc1F, Gc1S, Gc2 common alleles; Gc1A1, Gc1A8 variants observed.
• Pi system: Five alleles identified (PiM1, PiM2, PiM3, PiM4, PiX).
• Tf system: High variability with eight alleles (TfB1, TfC1-C4, TfC8, TfD1, TfDchi).
• Hp system: Two common (Hp1S, Hp1FS) and two rare alleles (Hp1F, Hp2SS) found.
• Reduced genetic polymorphism was noted in the isolated village population.

Conclusions:

• The study reveals significant genetic variability in serum proteins among Balinese populations.
• The isolated village exhibits reduced genetic polymorphism, consistent with population genetics principles.
• The findings contribute to understanding the anthropological history and genetic landscape of Bali.