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Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
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Mouse periodontitis models using whole Porphyromonas gingivalis bacteria induction
Ninuk Hariyani1,2, Anisa Nur Halimah1, Mohammed Al-Junaid3,4
1Dental Health Science Postgraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
The Saudi Dental Journal
|December 23, 2021
Summary
This review identifies key factors for creating mouse models of periodontitis using Porphyromonas gingivalis bacteria. Ligature combined with P. gingivalis is the most common method, but more efficient models are needed.
Area of Science:
- Periodontology
- Microbiology
- Animal Models
Background:
- Periodontitis prevalence necessitates research into disease progression and treatment efficacy.
- Mouse models are crucial for in vivo studies of periodontal disease.
- This review focuses on methods for creating mouse periodontitis models using Porphyromonas gingivalis.
Purpose of the Study:
- To conduct a scoping review of current literature on mouse periodontitis models.
- To identify methods for producing periodontitis models using Porphyromonas gingivalis.
- To inform future research on periodontitis modeling.
Main Methods:
- Scoping review methodology based on Arskey and O'Malley.
- Literature search conducted in the PubMed database.
- Data extraction and descriptive analysis of included articles.
Main Results:
- Eleven articles met the inclusion criteria.
- Key factors identified include vehicle, bacterial strain, application site, sacrifice day, and detection methods.
- Porphyromonas gingivalis combined with ligature is the most frequently used method.
Conclusions:
- The ligature and Porphyromonas gingivalis combination is the predominant method for inducing periodontitis in mice.
- Further research is needed to develop more effective and time-efficient periodontitis models.
- This review provides guidance for researchers developing future periodontitis models.
