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Updated: Oct 9, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
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Secondary Epileptogenesis: Common to See, but Possible to Treat?

Yujia Shen1,2, Yiwei Gong1,2, Yeping Ruan1

  • 1Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in Neurology
|December 23, 2021
PubMed

Keywords:
mechanismsneural circuitsneuromodulationpharmacotherapysecondary epileptogenesis

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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