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The Association with Subclinical Thyroid Dysfunction and Uric Acid.

Yuling Xing1,2, Linlin Yang3, Jing Liu1

  • 1Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050017, China.

International Journal of Endocrinology
|December 23, 2021
PubMed
Summary
This summary is machine-generated.

Subclinical thyroid dysfunction, including subclinical hypothyroidism, is linked to higher uric acid levels and an increased risk of hyperuricemia. Different thyroid conditions impact uric acid differently.

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Clinical Chemistry

Background:

  • The association between subclinical thyroid dysfunction and uric acid metabolism remains unclear.
  • Subclinical thyroid dysfunction encompasses subclinical hyperthyroidism and subclinical hypothyroidism.
  • Hyperuricemia is a significant risk factor for various metabolic and cardiovascular diseases.

Purpose of the Study:

  • To investigate the association between subclinical thyroid dysfunction and the risk of hyperuricemia.
  • To compare serum uric acid levels in patients with subclinical hyperthyroidism and subclinical hypothyroidism versus controls.
  • To evaluate the impact of different types of subclinical thyroid dysfunction on uric acid levels.

Main Methods:

  • Systematic literature search across four databases for relevant studies.
  • Meta-analysis using standardized mean difference (SMD) or odds ratio (OR) with 95% confidence intervals (CI).
  • Assessment of publication bias using funnel plots and Egger's/Begg's tests.

Main Results:

  • Serum uric acid levels were significantly higher in patients with subclinical hypothyroidism compared to controls and subclinical hyperthyroidism.
  • Subclinical thyroid dysfunction was associated with a higher prevalence of hyperuricemia compared to normal thyroid function.
  • Varied effects of different subclinical thyroid dysfunction types on serum uric acid levels were observed.

Conclusions:

  • Subclinical thyroid dysfunction is associated with an increased prevalence of hyperuricemia.
  • Subclinical hypothyroidism, in particular, is linked to elevated serum uric acid levels.
  • Further research is warranted to elucidate the mechanisms underlying these associations.