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Related Experiment Video

Updated: Oct 9, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Primary melanoma in the bronchus.

Akina Nigi¹, Hirokazu Toyoshima², Shigeto Kondo¹

¹Department of Respiratory Medicine Japanese Red Cross Ise Hospital Ise Japan.

Clinical Case Reports

|December 23, 2021

Summary

Primary malignant melanoma of the lung (PMML) is rare and hard to diagnose. This case study shows immunotherapy treatment for advanced PMML did not improve survival, with the patient dying 3 months later.

Keywords:

bronchoscopy primary malignant melanoma of the lung typical pigmentation

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Area of Science:

Oncology
Pulmonary Medicine
Dermatology

Background:

Primary malignant melanoma of the lung (PMML) is an exceptionally rare neoplasm.
PMML presents a diagnostic challenge, often confused with metastatic melanoma.
There is a lack of established treatment protocols for advanced PMML.

Purpose of the Study:

To report a case of advanced primary malignant melanoma of the lung treated with immunotherapy.
To highlight the diagnostic difficulties and poor prognosis associated with PMML.
To contribute to the limited understanding of treatment outcomes in PMML.

Main Methods:

A case presentation of a patient diagnosed with PMML.
Review of diagnostic procedures and challenges in differentiating PMML from metastatic disease.
Description of immunotherapy treatment administered to the patient.

Main Results:

The patient received immunotherapy for advanced PMML.
The patient's clinical outcome was poor, with death occurring 3 months post-treatment.
Diagnostic ambiguity between primary and metastatic lung melanoma persisted.

Conclusions:

Immunotherapy may not be an effective treatment for advanced primary malignant melanoma of the lung.
The dismal prognosis of PMML remains a significant clinical challenge.
Further research is needed to establish effective treatment strategies for PMML.