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The Relationship Between the Network of Non-coding RNAs-Molecular Targets and N6-Methyladenosine Modification in

Senxu Lu1,2, Xiangyu Ding1,2, Yuanhe Wang3

  • 1Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

Frontiers in Cell and Developmental Biology
|December 23, 2021
PubMed

Insights

Non-coding RNAs (ncRNAs) and N6-methyladenosine (m6A) methylation are key in colorectal cancer (CRC). This review details their interactions, offering potential for improved CRC diagnostics and therapeutics.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs), are increasingly recognized for their roles in colorectal cancer (CRC) pathogenesis.
  • N6-methyladenosine (m6A) methylation, a crucial epitranscriptomic modification, significantly influences ncRNA metabolism, affecting their stability and degradation pathways.
  • The intricate regulatory networks between ncRNAs and m6A modifications in the context of CRC remain incompletely understood.

Purpose of the Study:

  • To systematically review and summarize the interaction networks of ncRNAs in colorectal cancer.
  • To elucidate the interplay between m6A regulators and ncRNAs in CRC progression and metastasis.
  • To highlight the translational potential of ncRNAs and m6A modifiers as biomarkers and therapeutic targets for CRC.

Main Methods:

  • A data-driven approach was employed, analyzing publications with an impact factor greater than 6 from 2016 to 2021.
  • Literature review focused on identifying and characterizing ncRNA interaction networks and sub-networks within CRC.
  • The review extended to analyze the regulatory patterns involving core m6A regulators and their associated ncRNAs in CRC metastasis and progression.

Main Results:

  • Accumulated research implicates diverse ncRNAs in the initiation and development of colorectal cancer.
  • m6A methylation critically modulates ncRNA metabolism, impacting their functional roles in cancer.
  • Established interaction networks and regulatory patterns between ncRNAs and m6A machinery provide a framework for understanding CRC biology.

Conclusions:

  • ncRNA-ncRNA and ncRNA-m6A interactions form complex regulatory networks crucial for colorectal cancer development.
  • Understanding these networks offers insights into CRC metastasis and progression mechanisms.
  • ncRNAs and m6A modifiers represent promising avenues for developing novel diagnostic biomarkers and therapeutic strategies for colorectal cancer.
Keywords:
N6-methyladenosine modificationcolorectal cancerinteraction networklong non-coding RNAmicro RNA

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