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Comparison of celecoxib and acetaminophen for pain relief in pediatric day case tonsillectomy: A randomized
Mohammad Faramarzi1,2, Sareh Roosta2,3, Mohammad Hossein Eghbal4
1Department of Otorhinolaryngology - Head & Neck surgery Shiraz University of Medical Sciences Shiraz Iran.
Insights
Celecoxib provided better pain relief than acetaminophen on the first day after pediatric tonsillectomy. More children on celecoxib resumed a regular diet sooner, suggesting it is a more suitable pain management option.
Area of Science:
- Pediatric surgery
- Pain management
- Pharmacology
Background:
- Post-tonsillectomy pain is a significant cause of morbidity in children.
- Effective pain management is crucial for recovery and well-being after tonsillectomy.
Purpose of the Study:
- To compare the efficacy of celecoxib versus acetaminophen for pain relief in pediatric day-case tonsillectomy.
- To evaluate the impact on diet resumption and bleeding rates.
Main Methods:
- A randomized controlled trial comparing celecoxib (99 patients) with acetaminophen (100 patients).
- Pain scores were assessed thrice daily for 7 days.
- Post-tonsillectomy bleeding incidence and return to regular diet were recorded.
Main Results:
- Celecoxib demonstrated significantly lower mean pain scores on the first post-operative day (P = 0.013).
- No significant difference in overall pain scores on subsequent days.
- Patients receiving celecoxib resumed a regular diet within 3 days more frequently.
- Post-tonsillectomy bleeding rates were similar between groups.
Conclusions:
- Celecoxib is recommended over acetaminophen for managing post-tonsillectomy pain, particularly on the first day.
- Celecoxib facilitates earlier resumption of a regular diet within 3 days.
- This study supports celecoxib as a beneficial option for pediatric tonsillectomy pain management.
Objective:
Post-tonsillectomy pain is a common morbidity in children. The aim of this study was to compare the efficacy of celecoxib with acetaminophen on pain relief in pediatric day-case tonsillectomy.
Methods:
We compared the analgesic effect of celecoxib (99 patients) with acetaminophen (100 patients) for the management of post-tonsillectomy pain. Post-tonsillectomy pain score was evaluated three times a day for 7 days. In addition, the incidence of post-tonsillectomy bleeding and the rate of patients who returned to regular diet were evaluated.
Results:
In the first day, we observed lower mean pain score in the celecoxib group, than the acetaminophen group (P = 0.013). The overall pain score in other days was not significantly different between the two groups. In the celecoxib group, more patients resumed regular amount of oral intake within the first 3 days. Also, the rate of post-tonsillectomy bleeding in the two groups was not statistically different.
Conclusion:
We recommend celecoxib as a more suitable choice than acetaminophen for post-tonsillectomy pain management in the first day and resuming regular diet within 3 days.Level of Evidence: 1b.
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