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Double-negative T cells: Setting the stage for disease control or progression
Teresiama Velikkakam1,2, Kenneth J Gollob3,4, Walderez Ornelas Dutra1,2,4
1Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Immunology
|December 23, 2021
Summary
Double-negative (DN) T cells, though rare in human blood, are crucial immune orchestrators. Their dual role in tolerance and pathology highlights their complex nature and therapeutic potential.
Area of Science:
- Immunology
- Cell Biology
Background:
- Double-negative (DN) T cells lack CD4 and CD8 co-receptors but express T-cell receptors (TCRs).
- These cells are found at low frequencies in human peripheral blood.
- DN T cells are potent cytokine producers, influencing immune responses.
Purpose of the Study:
- To review the phenotypic and functional characteristics of DN T cells.
- To emphasize the role of DN T cells in human diseases.
- To discuss DN T cells as therapeutic targets.
Main Methods:
- Literature review of phenotypic and functional studies.
- Analysis of DN T cell roles in various human diseases.
- Discussion on biomarker development for translational studies.
Main Results:
- DN T cells exhibit heterogeneity, with roles in both immune tolerance and pathology.
- Their cytokine production impacts immune response orchestration.
- Evidence suggests potential for DN T cells in disease development or prevention.
Conclusions:
- DN T cells are heterogeneous immune cells with dual roles in human health and disease.
- Understanding their complex functions is key to developing targeted therapies.
- Biomarkers are needed to translate findings from animal models to human applications.
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