New approaches for the analysis of mast cell maturation, heterogeneity, and function

Mast cells are regarded as potentially critical participants in a wide variety of important biological processes. Yet it has been difficult to ascertain the precise contribution of mast cells to many of these reactions. In part, this reflects recognition that different populations of mast cells may vary in phenotype and therefore may express different functions. Another problem has been the lack of suitable model systems for identifying and quantitating the mast cell's unique roles in biological processes in intact animals. This review will outline the development of promising new approaches for analyzing mouse mast cell differentiation and phenotypic heterogeneity and for studying the roles of mast cells in vivo.