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SARS-CoV-2 Immunohistochemistry In Placenta

Dinesh Rakheja1,2, Kristina Treat3, Charles F Timmons1,2

  • 112334University of Texas Southwestern Medical Center, Dallas, TX, USA.

International Journal of Surgical Pathology
|December 23, 2021
PubMed

Compared to the parental SARS-CoV-2 virus, infections by the now dominant Delta variant of SARS-CoV-2 appear to be more common and more severe in pregnant women. The need for a robust, cheap, and quick method for diagnosing placental infection by SARS-CoV-2 has thus become more acute. Here, we describe a highly sensitive and specific immunohistochemical assay for SARS-CoV-2 nucleocapsid protein for routine use in placental pathology practice.

Keywords:
COVID-19SARS-CoV-2electron microscopyimmunohistochemistrynucleocapsid proteinplacentaspike proteinultrastructure

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