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Updated: Oct 9, 2025
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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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B cells in systemic lupus erythematosus
Franziska Szelinski1,2,3, Andreia C Lino1,2,3, Thomas Dörner1,2,3
1Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin.
Current Opinion in Rheumatology
|December 23, 2021
Summary
This review explores B cell abnormalities in systemic lupus erythematosus (SLE), identifying new pathogenic subsets and their role in immune protection. Understanding these B cell changes aids in developing targeted therapies for SLE patients.
Area of Science:
- Immunology
- Rheumatology
- Cell Biology
Background:
- Systemic lupus erythematosus (SLE) is characterized by significant B cell abnormalities.
- These abnormalities provide insights into B cell differentiation and dysregulation.
- Newly identified pathogenic B cell subsets and intrinsic B cell defects are observed in SLE.
Purpose of the Study:
- To review new insights into altered B cell distribution in SLE.
- To summarize the role of these B cells in immune protection.
- To discuss recent advancements in understanding B cell abnormalities in SLE.
Main Methods:
- Review of recent scientific literature on B cell subsets in SLE.
- Analysis of findings related to B cell differentiation and abnormalities.
- Examination of therapeutic targeting strategies for B cells in SLE.
Main Results:
- Expansion of specific antigen-experienced B cell subsets (lacking CD27, IgD, CXCR5, and CD19low) identified as plasmablasts in SLE.
- Advancements in understanding second-generation anti-CD20, anti-CD38, and CD19-CART therapies.
- Demonstration of the critical role of B cell requirements with T cells during SARS-CoV-2 infection and vaccination in patients with B cell impairments.
Conclusions:
- Identification and characterization of relevant B cell subsets and regulatory mechanisms in SLE are crucial.
- New approaches for targeting pathogenic B cells in SLE are facilitated by this understanding.
- Preservation of protective immune functions must be considered in therapeutic strategies.
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