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Light-Sensitive Phenacyl Crosslinked Dextran Hydrogels for Controlled Delivery.

Tobias G Brevé1, Mike Filius2, Sven Weerdenburg1

  • 1Department of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ, Delft, The Netherlands.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 23, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed light-sensitive polymer hydrogels for controlled drug release. These materials efficiently release proteins like bovine serum albumin and immunoglobulin G when exposed to specific light wavelengths, paving the way for targeted therapies.

Keywords:
controlled releasedextranhydrogelsphenacylphotocagespolymers

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Photochemistry

Background:

  • Stimuli-responsive soft materials offer controlled release of drugs and biomolecules.
  • Reducing side effects of potent chemotherapeutics and immunotherapeutics requires controlled release strategies.
  • Cerenkov luminescence presents a potential trigger for controlled release applications.

Purpose of the Study:

  • To develop polymer hydrogels for light-triggered controlled release of biomolecules.
  • To investigate the use of Cerenkov luminescence as a trigger for drug delivery.
  • To synthesize and characterize novel light-sensitive crosslinkers for hydrogel preparation.

Main Methods:

  • Synthesis and photochemical characterization of two phenacyl bis-azide crosslinkers.
  • Preparation of transparent, self-supporting hydrogel patches using the crosslinkers.
  • Evaluation of protein release (bovine serum albumin, immunoglobulin G) upon light irradiation (254 nm-375 nm).

Main Results:

  • Developed a π-extended phenacyl crosslinker with a high photocleavage quantum yield (14%) at 375 nm.
  • Demonstrated efficient and dose-controlled release of bovine serum albumin and immunoglobulin G from dextran hydrogels.
  • Observed significant overlap between the crosslinker's absorption and the Cerenkov luminescence emission window.

Conclusions:

  • Photosensitive soft materials based on phenacyl bis-azide crosslinkers enable light-triggered protein release.
  • The extended phenacyl crosslinker shows promise for radiation-targeted drug delivery applications.
  • Further investigation is needed to confirm Cerenkov-triggered release due to observed side-reactivity.