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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Neonatal chikungunya encephalitis.

R Sreekanth¹, Lakshmi Venugopal², B Arunkrishnan³

¹Resident Department of Neonatology, 80205Dr Mehta Multispeciality Hospital Chennai, Chennai, India.

Tropical Doctor

|December 23, 2021

Summary

This summary is machine-generated.

Chikungunya virus infection in newborns can mimic sepsis, requiring a high index of suspicion for diagnosis during outbreaks. Characteristic symptoms like rash and skin discoloration, confirmed by RT-PCR, aid in identifying this tropical viral disease.

Keywords:

Chikungunya Hyperpigmentation

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Area of Science:

Tropical medicine
Viral pathogenesis
Neonatal infections

Background:

Chikungunya is a mosquito-borne viral illness prevalent in tropical regions.
Perinatal transmission of Chikungunya virus to newborns is a significant concern.
Clinical presentation in neonates often resembles sepsis, complicating diagnosis.

Purpose of the Study:

To highlight the diagnostic challenges of Chikungunya in newborns.
To emphasize the importance of clinical suspicion during outbreaks.
To describe key clinical and laboratory findings for accurate diagnosis.

Main Methods:

Review of clinical presentations of Chikungunya in neonates.
Emphasis on differential diagnosis with neonatal sepsis.
Role of characteristic dermatological findings.
Importance of molecular diagnostic confirmation using RT-PCR.

Main Results:

Newborns with Chikungunya can present with symptoms mimicking sepsis.
Characteristic skin rash and perioral hyperpigmentation are key clinical indicators.
Early and accurate diagnosis is crucial for appropriate management.
RT-PCR provides definitive laboratory confirmation.

Conclusions:

Chikungunya poses a diagnostic challenge in neonates due to its sepsis-like presentation.
A high index of suspicion, especially during outbreaks, is essential.
Clinical signs coupled with RT-PCR confirmation are vital for timely diagnosis and management of perinatal Chikungunya infection.