Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Refining the Allostatic Self-Efficacy Theory of Fatigue and Depression Using Causal Inference.

Entropy (Basel, Switzerland)·2025
Same author

Correlations reveal the hierarchical organization of biological networks with latent variables.

Communications biology·2024
Same author

Post-COVID breathlessness: a mathematical model of respiratory processing in the brain.

European archives of psychiatry and clinical neuroscience·2024
Same author

Cristae-dependent quality control of the mitochondrial genome.

Science advances·2021
Same author

Regulatory encoding of quantitative variation in spatial activity of a <i>Drosophila</i> enhancer.

Science advances·2020
Same author

Network changes in patients with phobic postural vertigo.

Brain and behavior·2020

Related Experiment Video

Updated: Oct 9, 2025

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

4.2K

Distributed coding of duration in rodent prefrontal cortex during time reproduction.

Josephine Henke1,2, Raven Bunk1, Dina von Werder1

  • 1Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.

Elife
|December 23, 2021
PubMed
Summary

Gerbils exhibit primate-like magnitude estimation in time reproduction, showing a regression effect. Neural recordings reveal mixed responses in the medial prefrontal cortex are key to encoding this bias.

Keywords:
central tendencygerbilinterval timingmagnitude estimationneurosciencepopulation codingregression effect

More Related Videos

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments
09:43

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

Published on: April 15, 2014

10.7K
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

14.8K

Related Experiment Videos

Last Updated: Oct 9, 2025

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

4.2K
A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments
09:43

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

Published on: April 15, 2014

10.7K
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

14.8K

Area of Science:

  • Neuroscience
  • Comparative Cognition
  • Behavioral Biology

Background:

  • Magnitude estimation from sensory input is crucial for interacting with the environment.
  • While studied in primates, magnitude estimation in nonprimate species remains largely unexplored.
  • Time interval reproduction offers a behavioral paradigm to investigate magnitude estimation.

Purpose of the Study:

  • To investigate magnitude estimation characteristics in a nonprimate species (gerbils) using time interval reproduction.
  • To explore the neural correlates of magnitude estimation in the medial prefrontal cortex (mPFC).
  • To determine how neural activity patterns relate to behavioral biases in time reproduction.

Main Methods:

  • Behavioral experiments using time interval reproduction in gerbils.
  • Electrophysiological recordings from the medial prefrontal cortex (mPFC) during the task.
  • Analysis of neural firing patterns in relation to stimulus duration and reproduction accuracy.

Main Results:

  • Gerbils demonstrated primate-like magnitude estimation, including a regression effect (overestimation of short, underestimation of long intervals).
  • A majority of recorded mPFC neurons showed activity during either the stimulus measurement or reproduction phase.
  • Distinct neural response patterns were observed in cells active during both phases.
  • Only neural populations with mixed response patterns were found to encode the regression effect bias.

Conclusions:

  • Gerbils' time reproduction behavior mirrors primate magnitude estimation, suggesting conserved neural principles.
  • Medial prefrontal cortex activity, particularly mixed response patterns, is critical for encoding temporal magnitude estimation biases.
  • These findings provide insights into the neural basis of time perception and magnitude estimation across species.