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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

73
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue Transplantation01:24

Tissue Transplantation

569
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
569
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

548
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
548
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

88
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
88

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Study of Experimental Organ Donation Models for Lung Transplantation
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Donor selection for multiorgan transplantation.

Stephanie Hsiao1, Kiran K Khush

  • 1Cardiovascular Medicine, Stanford University, Stanford, California, USA.

Current Opinion in Organ Transplantation
|December 23, 2021
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Selecting donors for multiorgan transplantation is complex. This review outlines donor criteria for heart-kidney, heart-lung, and heart-liver transplants, guiding selection for better outcomes.

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Area of Science:

  • Transplantation immunology
  • Organ procurement
  • Surgical outcomes

Background:

  • Multiorgan transplantation is increasing.
  • Limited guidance exists for donor selection in multiorgan procedures.
  • Donor availability and short ischemic times are challenges.

Purpose of the Study:

  • Review Organ Procurement and Transplantation Network (OPTN) policy for multiorgan allocation.
  • Define ideal donor criteria for specific multiorgan transplant combinations.
  • Provide a framework for donor selection in multiorgan transplantation.

Main Methods:

  • Review of current OPTN policy.
  • Analysis of ideal donor characteristics for heart-kidney, heart-lung, and heart-liver transplants.
  • Synthesis of data on HLA matching and organ tolerance.

Main Results:

  • Heart-kidney transplants require stringent HLA matching; virtual crossmatch and desensitization can reduce wait times.
  • Ideal heart-lung donors are younger, tolerate HLA mismatch, and have no smoking history.
  • Livers show tolerance to HLA mismatch and may offer immune protection in combined transplants.

Conclusions:

  • Younger donor age, size matching, fewer comorbidities, and HLA compatibility are crucial for multiorgan transplant success.
  • Donor selection criteria vary significantly by organ combination.
  • Further research and standardized guidelines are needed for optimal donor selection.