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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics.

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Ageing and obesity are major health challenges sharing common molecular pathways and risk factors. Exercise and healthy lifestyles, impacting epigenetic changes, offer therapeutic benefits for both conditions, improving healthy ageing and obesity management.

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Area of Science:

  • Gerontology and metabolic health research.
  • Investigating the intersection of ageing, obesity, and epigenetics.

Background:

  • Ageing and obesity are significant global health challenges.
  • Both conditions share common cellular/molecular pathways and act as risk factors for numerous diseases.
  • Exercise and healthy lifestyles are primary therapeutic strategies for both ageing and obesity.

Purpose of the Study:

  • To explore the interrelations between ageing and obesity.
  • To understand the role of epigenetic modifications in the context of ageing and obesity.
  • To highlight exercise as a therapeutic intervention impacting these epigenetic pathways.

Main Methods:

  • Review of common features between ageing and obesity.
  • Analysis of shared risk factors and disease implications.
  • Examination of epigenetic changes (histone modification, DNA methylation, noncoding RNAs, chromatin remodeling) influenced by exercise.

Main Results:

  • Ageing and obesity share common molecular mechanisms and disease risks.
  • Epigenetic alterations are common to both ageing and obesity.
  • Exercise positively impacts these epigenetic modifications.

Conclusions:

  • Epigenetic pathways mediate the benefits of exercise in managing ageing and obesity.
  • Understanding these interrelations can optimize therapeutic strategies.
  • This research supports improved obesity management and promotes healthy ageing.