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The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review
Tamara Alhobayb1, Rahul Peravali2, Motaz Ashkar1
1Department of Medicine, Division of Gastroenterology, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor prognosis, leading to significant cancer-related mortality and an overall five-year survival rate of about nine percent. Acute and chronic pancreatitis have been associated with PDAC through common risk factors based on multiple epidemiological studies. Acute pancreatitis (AP) might be one of the earliest manifestations of PDAC, but evolving chronic pancreatitis (CP) following recurrent bouts of AP has been proposed as a risk factor for cancer development in the setting of persistent inflammation and ongoing exposure to carcinogens. This review aims to highlight the evidence supporting the relationship between acute and chronic pancreatitis with PDAC.
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