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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

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An Ecchymosis with Fulminant Evolution.

Andrea Michelerio^1,2, Stefania Barruscotti^1,2, Nathalie Rizzo³

¹Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

Dermatopathology (Basel, Switzerland)

|December 23, 2021

Summary

This case study highlights an aggressive cutaneous angiosarcoma on the head. Rapid tumor growth and delayed healthcare access due to COVID-19 significantly impacted the patient's outcome.

Keywords:

angiosarcoma hemangiosarcoma hemangiosarcoma/mortality vascular tissue neoplasm

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Area of Science:

Oncology
Dermatology
Pathology

Background:

Cutaneous angiosarcoma is a rare and aggressive vascular tumor.
Head and neck region is a common site for angiosarcoma.
Early diagnosis and prompt treatment are crucial for favorable prognosis.

Observation:

An 83-year-old woman presented with a rapidly progressing cutaneous angiosarcoma on her forehead.
The tumor initially appeared as a small ecchymosis.
Photographic evidence documented the dramatic and swift evolution of the lesion.

Findings:

Fulminant tumor growth was observed.
Delayed access to medical care, exacerbated by COVID-19 pandemic lockdowns, contributed to advanced disease stage.
The combination of rapid progression and delayed treatment led to a poor patient outcome.

Implications:

This case underscores the importance of timely medical evaluation for suspicious skin lesions.
The impact of external factors, such as pandemics, on healthcare access and patient outcomes warrants consideration.
Further research into aggressive cutaneous angiosarcoma management strategies is needed.